Pharmacogenetics of Alcohol and Alcohol Dependence Treatment

Alcohol Dependence--neurobiology and Treatment.

The consequences of alcohol dependence concern serious health care, social and economic problems. The scope of many studies is to better understand mechanisms underlying alcohol addiction in order to work out new, more effective treatment strategies. Alcohol affects many neurotransmission systems within the brain. In general, acute alcohol enhances inhibitory transmission, up-regulating the GAB...

Alcohol Dependence Medication Treatment Algorithm

Treatment of Adolescent Alcohol Abuse and Dependence

A abuse and alcohol de­ pendence1 are not only adult problems. They also affect a significant portion of adoles­ cents between the ages of 12 and 18, even though the purchase and public use of alcohol are illegal for them. Diagnosis and treatment of these disorders are important because alcohol­related problems can have an enormous impact on the adolescents’ future. Early alcohol abuse can lead...

Opioid pharmacogenetics of alcohol addiction.

Alcohol addiction is one of the most common and devastating diseases in the world. Given the tremendous heterogeneity of alcohol-addicted individuals, it is unlikely that one medication will help nearly all patients. Thus, there is a clear need to develop predictors of response to existing medications. Naltrexone is a μ-opioid receptor antagonist, which has been approved in the United States fo...

Alcohol Dependence and Mortality: Implications for Treatment

Article history: Received 15 September 2015 Accepted 15 September 2015 Available online 16 September 2015 showed an increase inmortality of 25% among those with alcohol dependence compared to thosewith criteria for the diagnosis alcohol abuse suggesting an increased severity of this diagnosis in terms of health risk, even if the two conditions represent an underlying continuum. Roerecke and Reh...